Biochemical Reagents
ABclonal Technology TriMethyl-Histone H3-K4
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A H2B H3 and H4) The chromatin fiber is further compacted through the interaction of a linker histone H1 with the DNA between the nucleosomes to form higher order chromatin structures This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family Transcripts from this gene lack polyA tails instead they contain a palindromic termination element This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21 3
Medchemexpress LLC Succinate/succinate receptor antagonist 1 | 2361972-29-2 | C17H15N3O | 100 MG
Succinate/succinate receptor antagonist 1 is an antagonist of the succinate/succinate receptor. It can inhibit the activation of succinate receptor 1 (SUCNR1) and block succinate signaling in gingival tissue. This compound can be used for the study of periodontal disease. In vitro, at 10 μM for 24 hours, it significantly inhibits SUCNR1 activation and blocks succinate-mediated receptor signaling in human SUCNR1 AequoScreen cells.
- Inhibits activation of succinate receptor 1 (SUCNR1)
- Blocks succinate signaling in gingival tissue
- Useful for the study of periodontal disease
Medchemexpress LLC Prt062607 (acetate) | 1370261-98-5 | C21H27N9O3 | 25 MG
PRT062607 (acetate) is a laboratory chemical intended for research use by experienced personnel. It is stable under recommended storage conditions and is not classified as a hazardous substance or mixture.
- Not a hazardous substance or mixture.
- Stable under recommended storage conditions.
- Suitable for laboratory use.
Medchemexpress LLC Alpha-Guanosine | 15398-66-0 | C10H13N5O5 | 25 MG
Alpha-Guanosine is a purine nucleoside analog that exhibits broad antitumor activity against indolent lymphoid malignancies. Its anticancer mechanisms involve inhibiting DNA synthesis and inducing apoptosis.
- Purine nucleoside analog
- Exhibits broad antitumor activity
- Targets indolent lymphoid malignancies
- Inhibits DNA synthesis
- Induces apoptosis
Cayman Chemical 3-hydroxy-DL-KynurenIn 25mg
An active metabolite of tryptophan; inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%, respectively, at 100 μM; active against MRSA, S. epidermidis, VRE, E. coli, MDRP, and C. albicans (IC50s = 31.2, 39.2, 57.6, 24, 25.6, and 137.6 μg/ml, respectively); increases intracellular NAD+ levels and extracellular LDH activity in human neurons and astrocytes
eMolecules (S)-(+)-1-FMOC-3-HYDROXYPYRROLIDINE | 215178-38-4 | MFCD01317842 | 5g
AstaTech | (S)-(+)-1-FMOC-3-HYDROXYPYRROLIDINE | 5g | 397208884 | 61134 | 97.000 | 215178-38-4 | MFCD01317842 | 309.365 | C19H19NO3
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TARGETMOL CHEMICALS INC Solifenacin succinate 500MG
Also available in 1 g, 1 mL, 50 mg, 100 mg and bulk. Please contact Fisher for quotes.Solifenacin succinate (YM905) is a quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INCONTINENCE. Purity 99.73%
TARGETMOL CHEMICALS INC Z-2-decenoic acid 10MG
Also available in 1 mL, 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. (Z)-2-decenoic acid (cis-dec-2-enoic acid) is an unsaturated short-chain fatty acid secreted by Pseudomonas aeruginosa. It can induce a dispersion response in biofilms formed by gram-negative and gram-positive bacteria and can also inhibit biofilm development.
Biotium PAX8 (Renal Cell Marker) (PAX8/1491), CF640R conjugate, 0.1mg/mL
This antibody recognizes a protein of 62 kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.Primary antibodies are available purified, o
Biotium CD4 (T-Helper/Inducer Cell Marker)(CD4/1604), CF405S conjugate, 0.1mg/mL
The immunogen for this Mab is derived from the extracellular domain of CD4, a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. The majority of peripheral T-cell lymphomas are derived from the T-helper/regulatory cell subset so that most mature T-cell neoplasms are CD4 /CD8-. Anti-CD4 is used in the immunohistochemical staining of lymphoproliferative disorders to evaluate tumors with CD4 aberrant expression.Primary antibodies are available purified, or with a selection of fluore
Medchemexpress LLC N-acetyl-L-cysteine ethyl ester | 59587-09-6 | MFCD09954466 | 99.9% | 191.25 g/mol | C7H13NO3S | 5 MG
N-Acetyl-L-cysteine ethyl ester (NACET) is the ethyl-ester derivative of N-acetyl-L-cysteine with enhanced membrane permeability. It is provided as a research-grade small molecule solid for biochemical and cell-based studies involving thiol delivery, glutathione metabolism, and modulation of reactive oxygen species.
- Improved cell permeability compared with the parent compound.
- Precursor to N-acetylcysteine and intracellular glutathione.
- Useful in oxidative stress and redox biology studies.
- Suitable for small-scale exploratory experiments and assays.
- Supplied as a solid with defined molecular weight and chemical formula.
Biotium SREBP2(SREBP2/1579), CF405S conjugate, 0.1mg/mL
The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates o
Biotium CD357 / GITR(GITR/1585), CF405S conjugate, 0.1mg/mL
The tumor necrosis factor receptor (TNFR) superfamily represents a growing family of type I transmembrane glycoproteins that are involved in various cellular functions, including proliferation, differentiation and programmed cell death. These proteins share homology for cysteine-rich repeats in the extracellular ligand binding domain and an intracellular death domain. Members of the TNFR superfamily transmit signals through protein-protein interactions, and these signals can lead to the activation of either the caspase and Jun kinase pathways, which promote cell death, or the NFB signaling pathway. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other
Medchemexpress LLC Cytarabine triphosph 25mg | 1179343-17-9 | 25 MG
Cytarabine triphosphate trisodium is the trisodium salt of cytarabine triphosphate and is used as a research reagent to study DNA synthesis inhibition and nucleoside metabolism.
- Trisodium salt form supplied as a solution.
- Pack size 25 mg, prepared as 100 mM x 500 μL in water for the 25 mg vial.
- Molecular formula C9H13N3Na3O14P3 and molecular weight 549.10 g/mol.
- Purity approximately 96.8%.
- Storage: solution at -20°C; prepared stock solution stability: -80°C for 6 months, -20°C for 1 month.
- Used as the active metabolite Ara-CTP in biochemical and cell-based assays targeting DNA synthesis.
